Sabbagh, G., Fettes, K.J., Gosain, R., O'Neil, I.A. Synthesis of 3′-thioribouridine, 3′-thioribocytidine, and their phosphoramidites. Synthesis and properties of dithymidine phosphate analogs containing 3′-thiothymidine. Solid-phase synthesis of oligonucleotides containing 3′-thiothymidine. Application of the Michaelis-Arbuzov reaction to the synthesis of internucleoside 3′-S-phosphorothiolate linkages. New methods for the synthesis of 3′-S-phosphorothiolate internucleoside linkages. Stabilization of the DNA I-motif structure by incorporation of 3′-S-phosphorothiolate linkages. Probing the effect of a 3′-S-phosphorothiolate link on the conformation of a DNA: RNA hybrid implications for antisense drug design. Conformational analysis of 3′-S-PO3-linked ribo- and deoxyribodinucleoside monophosphates. Mechanism of the Escherichia coli DNA T: G-mismatch endonuclease (Vsr protein) thiophosphate-containing probed with oligodeoxynucleotides. The RuvC protein dimer resolves Holliday junctions by a dual incision mechanism that involves base-specific contacts. Structures of normal single-stranded DNA and deoxyribo-3′-S-phosphorothiolates bound to the 3′-5′ exonucleolytic active site of DNA polymerase I from Escherichia coli. Functional evidence that the 3′-5′ exonuclease domain of Escherichia coli DNA polymerase I employs a divalent metal ion in leaving group stabilization. Bridging sulfur substitutions in the analysis of pre-mRNA splicing. Synthesis of 3′-thioribonucleosides and their incorporation into oligoribonucleotides via phosphoramidite chemistry. Synthesis and characterization of an RNA dinucleotide containing a 3′-S-phosphorothiolate linkage.

Weinstein, L.B., Earnshaw, D.J., Cosstick, R. Inhibition of EcoRV endonuclease by deoxyribo-3′-S-phosphorothiolates: a high-resolution X-ray crystallographic study. Sequence-specific binding of DNA by the EcoRV restriction and modification enzymes with nucleic-acid and cofactor analogues. Metal-ion catalysis in the Tetrahymena ribozyme reaction. Piccirilli, J.A., Vyle, J.S., Caruthers, M.H. Sequence-specific and strand-specific cleavage in oligodeoxyribonucleotides and DNA containing 3′-thiothymidine.

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